Medications for Depression in Late Life
by Robert Dolgoff, MD
Medical Director, Mental Health Services, Alta Bates Summit Medical Center
Medical Director, Berkeley Therapy Institute
Reprinted from Engaging Aging e-Newsletter, May 2011, Pages 4-5
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Anyone can get depressed at any time in life. Most people don’t realize that the rate of depression in seniors living in the community is rather low – most seniors living at home, especially if they are physically healthy, report that they are more content and happy than at any other time of their lives. The incidence of depression in institutional settings, however, is very high, approaching 50% or even more in some studies. This is probably because seniors in institutional settings are not physically healthy and they have been uprooted from the lives and people that provided emotional gratification and support.
The three pillars of treatment for all psychiatric disorders throughout the lifespan are:
- Psychotherapy or Counseling
- Psychosocial support from family, friends, and the community; and,
- Medications.
Medical illnesses can cause depression or can make depressive disorders worse. Thus it is important for an older adult who has become depressed to have a full medical evaluation, including basic lab work and possibly other diagnostic studies. Sometimes the treatment of a medical condition can also treat the depression! When I see an older adult who has a mental health problem I want to be sure that the treatment will be comprehensive, but when the depression is mild, medication may not be needed.
When the depression is moderate or severe and medical causes have been ruled out and when patients aren’t improving with counseling and psychosocial support we turn to medications. In my experience this is usually very successful and the person’s suffering can be relieved. I hope here to provide a very broad and necessarily brief survey of the psychopharmacological treatment of depression in the aged. Most readers of Engaging Aging will have some basic familiarity with the drugs that are used for depression in young and middle aged adults. The medications used in late life are the same but there are differences in dosing and in side effects in the elderly.
At one time there was little scientific evidence about how seniors do with antidepressants. Now numerous studies have been done in geriatric populations; a survey published in 2007 cited more than 30 randomized clinical trials with 5,000 geriatric subjects.
The antidepressants that are commonly used in early and middle life have been found to work well in the elderly and they have been shown to be safe even if the depressed person has mild cognitive impairment or even dementia. Citalopram (Celexa), Sertraline (Zoloft), and Escitalopram (Lexapro) have certain advantages over the other drugs. These three drugs are less likely than others to have unpleasant or dangerous interactions with other drugs that patients may be taking. The first two on the list are generic and so are more affordable. Common side effects of nearly all antidepressants for patients in all age groups are gastrointestinal disturbances, jitteriness, sedation or mental fogginess, weight gain, and impairment of sexual function. Patients with bipolar disorder (diagnosed or not-yet diagnosed) may become so overstimulated when given antidepressants that they can actually become manic. Most patients don’t get any of these side effects or if those side effects do occur they are mild. Older adults should be started on low doses of antidepressants – usually 50% of the dose one would give to a young or middle aged adult. Then the dose can be raised slowly. This is because many but not all drugs are metabolized more slowly in the elderly than in young people. Also older persons may have concurrent medical problems and may be on a number of other medications, thus making adverse drug interactions more likely to occur.
There are a few side effects which are seen at times in young and middle-aged patients which may be more prominent or serious in the elderly. Some antidepressants can impair blood-clotting and bleeding may occur; this may be particularly risky for seniors who are already on aspirin or other drugs that impair clotting. It is thought that antidepressants may cause osteoporosis or thinning of the bones. Antidepressants may slow the heart, and this could present problems for seniors who are taking other medications which may do that as well, for example drugs for high blood pressure. Also some antidepressants may at times cause sleepiness or sedation and/or may lower blood pressure making it a bit more likely that a person taking the medication might fall.
If one medication does not provide benefit another should be tried. Unfortunately it is not possible to predict what the right drug will be for an individual patient. Ultimately most people will get better! There is a lot of hope for geriatric patients who suffer from depression, especially if there is a comprehensive approach to their care, with attention to counseling or psychotherapy, psychosocial support from friends, family, and the community, and thoughtfully prescribed and monitored antidepressant medications.